N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide

N-hydroxy-4-({4-[4-(trifluoromethyl)phenoxy]phenyl}sulfonyl)tetrahydro-2H-pyran-4-carboxamide is an experimental small molecule belonging to the diarylether (diphenylether) class. It has a molecular formula of C₁₉H₁₈F₃NO₆S and a molecular weight of approximately 445.41 g/mol[2][3][5]. The compound is not approved for any indication and has not advanced beyond preclinical or early research phases. Its known mechanism involves targeting "a disintegrin and metalloproteinase with thrombospondin motifs 5" (ADAMTS5), suggesting potential utility as an ADAMTS5 inhibitor, which may be relevant in diseases involving extracellular matrix remodeling such as osteoarthritis[2]. No clinical trials or marketed products are associated with this compound.

Other names

N-hydroxy-4-{4-[4-(trifluoromethyl)phenoxy]benzenesulfonyl}oxane-4-carboxamide2H-Pyran-4-carboxamide, tetrahydro-N-hydroxy-4-{[4-[4-(trifluoromethyl)phenoxy]phenyl]sulfonyl}-